Compound Detail
CHEMBL242456
JNJ 2408068 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL242456 |
| Name | JNJ 2408068 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RDQSNNMSDOHAPG-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
1
PK Parameters
8
Publications
1
Known Names
Molecular Properties
394.5
MW (Da)
2.64
ALogP
7
HBA
3
HBD
92.2
PSA (Ų)
0.60
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 9.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fusion glycoprotein F0 CHEMBL2364165 | EC50 | 9.8 | 9.8 | 0.2 | 1 |
| Respiratory syncytial virus CHEMBL612679 | EC50 | 9.8 | 9.6667 | 0.2 | 3 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 153.0 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Respiratory syncytial virus | EC50 | = | 0.16 | nM | 9.8 | Antiviral activity against Respiratory syncytial virus infected cell system asse... | - |
| Fusion glycoprotein F0 | EC50 | = | 0.16 | nM | 9.8 | Inhibition of RSV Long fusion protein assessed as decrease in virus induced sync... | 30339388 |
| Respiratory syncytial virus | EC50 | = | 0.2512 | nM | 9.6 | Antiviral activity against RSV in HeLaM cells | 17722899 |
| Respiratory syncytial virus | EC50 | = | 0.2512 | nM | 9.6 | Inhibition of RSV by MTT assay | 18254606 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17722899 | 10.1021/jm070143x | Lung | 5 |
| 17722899 | 10.1021/jm070143x | Plasma | 2 |
| - | 10.1007/s00044-010-9533-9 | Respiratory syncytial virus | 2 |
| 17722899 | 10.1021/jm070143x | Respiratory syncytial virus | 1 |
| 17722899 | 10.1021/jm070143x | ADMET | 1 |
| 18254606 | 10.1021/jm701284j | Respiratory syncytial virus | 1 |
| 18254606 | 10.1021/jm701284j | NON-PROTEIN TARGET | 1 |
| 30339388 | 10.1021/acs.jmedchem.8b01394 | Fusion glycoprotein F0 | 1 |
Data from ChEMBL 36 via Core Engine