Assay Detail
Functional
CHEMBL896341
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Antiproliferative activity against human H1299 cells by FACS assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
1,4-Dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: extended exploration on phenyl ring substitutions and preliminary ADME/PK studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.36 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL234871 | — | — | 1 | 5.51 |
| CHEMBL232810 | — | — | 1 | 5.29 |
| CHEMBL234868 | — | — | 1 | 5.28 |
| CHEMBL399215 | — | — | 1 | - |
| CHEMBL233640 | — | — | 1 | - |
| CHEMBL234867 | — | — | 1 | - |
| CHEMBL232804 | — | — | 1 | - |
| CHEMBL234656 | — | — | 1 | - |
| CHEMBL392516 | — | — | 1 | - |
| CHEMBL234654 | — | — | 1 | - |
| CHEMBL391450 | — | — | 1 | - |
| CHEMBL234479 | — | — | 1 | - |
| CHEMBL393603 | — | — | 1 | - |
| CHEMBL232392 | — | — | 1 | - |
| CHEMBL428196 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL234871 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL232810 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL234868 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL399215 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL233640 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL234867 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL232804 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL234656 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL392516 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL234654 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL391450 | — | EC50 | - | — | - | |
| CHEMBL234479 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL393603 | — | EC50 | - | — | - | |
| CHEMBL232392 | — | EC50 | - | — | - | |
| CHEMBL428196 | — | EC50 | > | 10000.0 | nM | - |