Assay Detail
Binding
CHEMBL896431
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Inhibition of DPP9
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.58 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392924 | — | — | 1 | 5.26 |
| CHEMBL233564 | — | — | 1 | 4.34 |
| CHEMBL233563 | — | — | 1 | 4.14 |
| CHEMBL233360 | — | — | 1 | - |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392924 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL233564 | — | IC50 | = | 45400.0 | nM | 4.34 |
| CHEMBL233563 | — | IC50 | = | 72300.0 | nM | 4.14 |
| CHEMBL233360 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1422 | SITAGLIPTIN | IC50 | > | 100000.0 | nM | - |