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Assay Detail

CHEMBL896487

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Functional
Antiviral activity against HCMV in human foreskin fibroblast assessed as inhibition of virus plaque formation
ChEMBL ↗
41
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human betaherpesvirus 5
Confidence 1 — Organism
Curated By Intermediate

Target

Human betaherpesvirus 5 (CHEMBL371) ↗
Type ORGANISM
Organism Human betaherpesvirus 5

Publication

7-Oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides: synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase.
Larsen SD, Zhang Z, DiPaolo BA, Manninen PR, Rohrer DC, Hageman MJ, Hopkins TA, Knechtel ML, Oien NL, Rush BD, Schwende FJ, Stefanski KJ, Wieber JL, Wilkinson KF, Zamora KM, Wathen MW, Brideau RJ.
Bioorg Med Chem Lett (2007) 17 : 3840 -3844
PubMed 17513108 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 41 7.30 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL232755 — — 1 9.40
CHEMBL233612 — — 1 9.40
CHEMBL232115 — — 1 8.70
CHEMBL233614 — — 1 8.70
CHEMBL232953 — — 1 8.40
CHEMBL231913 — — 1 8.40
CHEMBL231914 — — 1 8.00
CHEMBL391438 — — 1 7.82
CHEMBL400836 — — 1 7.82
CHEMBL232753 — — 1 7.70
CHEMBL394023 — — 1 7.52
CHEMBL232562 — — 1 7.46
CHEMBL400604 — — 1 7.40
CHEMBL428190 — — 1 7.40
CHEMBL232954 — — 1 7.30
CHEMBL399798 — — 1 7.22
CHEMBL399594 — — 2 7.22
CHEMBL233613 — — 1 7.00
CHEMBL233179 — — 1 7.00
CHEMBL269005 — — 1 7.00
CHEMBL400605 — — 1 6.82
CHEMBL231701 — — 1 6.82
CHEMBL232361 — — 1 6.35
CHEMBL233804 — — 1 6.30
CHEMBL232564 — — 1 6.30
CHEMBL232563 — — 1 6.10
CHEMBL182 GANCICLOVIR 4.0 1 5.89
CHEMBL232952 — — 1 5.38
CHEMBL233425 — — 1 4.82
CHEMBL232754 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL232755 — IC50 = 0.4 nM 9.40
CHEMBL233612 — IC50 = 0.4 nM 9.40
CHEMBL232115 — IC50 = 2.0 nM 8.70
CHEMBL233614 — IC50 = 2.0 nM 8.70
CHEMBL232953 — IC50 = 4.0 nM 8.40
CHEMBL231913 — IC50 = 4.0 nM 8.40
CHEMBL231914 — IC50 = 10.0 nM 8.00
CHEMBL400836 — IC50 = 15.0 nM 7.82
CHEMBL391438 — IC50 = 15.0 nM 7.82
CHEMBL232753 — IC50 = 20.0 nM 7.70
CHEMBL394023 — IC50 = 30.0 nM 7.52
CHEMBL232562 — IC50 = 35.0 nM 7.46
CHEMBL400604 — IC50 = 40.0 nM 7.40
CHEMBL428190 — IC50 = 40.0 nM 7.40
CHEMBL232954 — IC50 = 50.0 nM 7.30
CHEMBL399798 — IC50 = 60.0 nM 7.22
CHEMBL399594 — IC50 = 60.0 nM 7.22
CHEMBL399594 — IC50 = 60.0 nM 7.22
CHEMBL269005 — IC50 = 100.0 nM 7.00
CHEMBL233613 — IC50 = 100.0 nM 7.00
CHEMBL233179 — IC50 = 100.0 nM 7.00
CHEMBL400605 — IC50 = 150.0 nM 6.82
CHEMBL231701 — IC50 = 150.0 nM 6.82
CHEMBL232361 — IC50 = 450.0 nM 6.35
CHEMBL233804 — IC50 = 500.0 nM 6.30
CHEMBL232564 — IC50 = 500.0 nM 6.30
CHEMBL232563 — IC50 = 800.0 nM 6.10
CHEMBL182 GANCICLOVIR IC50 = 1300.0 nM 5.89
CHEMBL232952 — IC50 = 4200.0 nM 5.38
CHEMBL233425 — IC50 = 15000.0 nM 4.82
CHEMBL233556 — IC50 > 1000.0 nM -
CHEMBL392777 — IC50 > 5000.0 nM -
CHEMBL232754 — IC50 - — -
CHEMBL233558 — IC50 > 5000.0 nM -
CHEMBL394024 — IC50 - — -
CHEMBL231700 — IC50 - — -
CHEMBL231706 — IC50 - — -
CHEMBL233770 — IC50 - — -
CHEMBL184 ACYCLOVIR IC50 > 20000.0 nM -
CHEMBL233424 — IC50 - — -
CHEMBL233557 — IC50 - — -