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Assay Detail

CHEMBL896500

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Binding
Inhibition of PTP1B
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B.
Na M, Hoang DM, Njamen D, Mbafor JT, Fomum ZT, Thuong PT, Ahn JS, Oh WK.
Bioorg Med Chem Lett (2007) 17 : 3868 -3871
PubMed 17517504 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 6 4.49 4.87

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL232935 2'-O-DEMETHYLBIDWILLOL B 1 4.87
CHEMBL232941 ADDISOFURAN B 1 4.80
CHEMBL233142 ADDISOFURAN A 1 4.76
CHEMBL233147 1 4.20
CHEMBL233766 1 4.19
CHEMBL233767 1 4.13

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL232935 2'-O-DEMETHYLBIDWILLOL B IC50 = 13600.0 nM 4.87
CHEMBL232941 ADDISOFURAN B IC50 = 15700.0 nM 4.80
CHEMBL233142 ADDISOFURAN A IC50 = 17500.0 nM 4.76
CHEMBL233147 IC50 = 62700.0 nM 4.20
CHEMBL233766 IC50 = 64900.0 nM 4.19
CHEMBL233767 IC50 = 74100.0 nM 4.13