Assay Detail
Binding
CHEMBL896596
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Displacement of [3H]SCH-23390 from rat dopamine D1 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.57 | 5.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444368 | — | — | 1 | 5.86 |
| CHEMBL392447 | — | — | 1 | 5.75 |
| CHEMBL233567 | — | — | 1 | 5.70 |
| CHEMBL233566 | — | — | 1 | 5.55 |
| CHEMBL53510 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444368 | — | Ki | = | 1390.0 | nM | 5.86 |
| CHEMBL392447 | — | Ki | = | 1780.0 | nM | 5.75 |
| CHEMBL233567 | — | Ki | = | 1980.0 | nM | 5.70 |
| CHEMBL233566 | — | Ki | = | 2790.0 | nM | 5.55 |
| CHEMBL53510 | — | Ki | = | 9650.0 | nM | 5.01 |