Assay Detail
Binding
CHEMBL896618
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Inhibition of calf PNP in presence of 1 mM phosphate
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.86 | 7.99 |
| Ki | 2 | 8.30 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL236709 | — | — | 2 | 8.36 |
| CHEMBL236711 | — | — | 1 | 8.24 |
| CHEMBL236708 | — | — | 1 | 7.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL236709 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL236711 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL236709 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL236708 | — | IC50 | = | 18.7 | nM | 7.73 |