Assay Detail
Functional
CHEMBL896645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at GR by GRE activation assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
5(Z)-benzylidene-1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes as non-steroidal glucocorticoid receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 7.89 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243455 | — | — | 1 | 9.70 |
| CHEMBL3706960 | — | — | 1 | 9.70 |
| CHEMBL3706932 | — | — | 1 | 9.22 |
| CHEMBL3706962 | — | — | 1 | 9.15 |
| CHEMBL3706956 | — | — | 1 | 8.96 |
| CHEMBL3706946 | — | — | 1 | 8.82 |
| CHEMBL3706961 | — | — | 1 | 8.82 |
| CHEMBL3706934 | — | — | 1 | 8.47 |
| CHEMBL3706935 | — | — | 1 | 8.35 |
| CHEMBL3706936 | — | — | 1 | 8.29 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 8.28 |
| CHEMBL3706938 | — | — | 1 | 8.26 |
| CHEMBL3706940 | — | — | 1 | 7.80 |
| CHEMBL3706933 | — | — | 1 | 7.75 |
| CHEMBL3706955 | — | — | 1 | 7.48 |
| CHEMBL3706952 | — | — | 1 | 7.42 |
| CHEMBL3706951 | — | — | 1 | 7.37 |
| CHEMBL3706937 | — | — | 1 | 7.10 |
| CHEMBL3706939 | — | — | 1 | 6.97 |
| CHEMBL3706957 | — | — | 1 | 6.88 |
| CHEMBL3706942 | — | — | 1 | 6.72 |
| CHEMBL3706953 | — | — | 1 | 6.68 |
| CHEMBL3706941 | — | — | 1 | 6.45 |
| CHEMBL3706958 | — | — | 1 | 6.36 |
| CHEMBL3706954 | — | — | 1 | 6.34 |
| CHEMBL3706950 | — | — | 1 | - |
| CHEMBL3706949 | — | — | 1 | - |
| CHEMBL3706948 | — | — | 1 | - |
| CHEMBL3706947 | — | — | 1 | - |
| CHEMBL3706945 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243455 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3706960 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3706932 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3706962 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3706956 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3706946 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3706961 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3706934 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3706935 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3706936 | — | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL131 | PREDNISOLONE | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3706938 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL3706940 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3706933 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3706955 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3706952 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3706951 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3706937 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3706939 | — | EC50 | = | 108.0 | nM | 6.97 |
| CHEMBL3706957 | — | EC50 | = | 133.0 | nM | 6.88 |
| CHEMBL3706942 | — | EC50 | = | 192.0 | nM | 6.72 |
| CHEMBL3706953 | — | EC50 | = | 207.0 | nM | 6.68 |
| CHEMBL3706941 | — | EC50 | = | 356.0 | nM | 6.45 |
| CHEMBL3706958 | — | EC50 | = | 437.0 | nM | 6.36 |
| CHEMBL3706954 | — | EC50 | = | 455.0 | nM | 6.34 |
| CHEMBL3706950 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL3706949 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL3706948 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL3706947 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL3706945 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL3706944 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL3706943 | — | EC50 | > | 1000.0 | nM | - |