Assay Detail
Functional
CHEMBL896687
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Growth inhibition against Trypanosoma brucei brucei
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.24 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 7.11 |
| CHEMBL55225 | — | — | 1 | 6.75 |
| CHEMBL393580 | — | — | 1 | 6.58 |
| CHEMBL236826 | — | — | 1 | 5.80 |
| CHEMBL393396 | — | — | 1 | 5.80 |
| CHEMBL236160 | — | — | 1 | 5.40 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | - |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | - |
| CHEMBL237003 | — | — | 1 | - |
| CHEMBL237002 | — | — | 1 | - |
| CHEMBL237001 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL55225 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL393580 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL236826 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL393396 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL236160 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL61 | PODOFILOX | IC50 | - | — | - | |
| CHEMBL55 | PENTAMIDINE | IC50 | - | — | - | |
| CHEMBL237003 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL237002 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL237001 | — | IC50 | > | 50000.0 | nM | - |