Assay Detail
Functional
CHEMBL896755
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Cytotoxicity against NQO2 expressing human RT112 cells by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RT-112 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of cryptolepine analogues as potential bioreducible anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.02 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL609689 | — | — | 1 | 6.62 |
| CHEMBL609428 | — | — | 1 | 6.54 |
| CHEMBL609688 | — | — | 1 | 6.44 |
| CHEMBL609426 | — | — | 1 | 6.39 |
| CHEMBL609685 | — | — | 1 | 6.35 |
| CHEMBL609687 | — | — | 1 | 6.12 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | — | 1 | 6.09 |
| CHEMBL609427 | — | — | 1 | 6.06 |
| CHEMBL609686 | — | — | 1 | 5.99 |
| CHEMBL609430 | — | — | 1 | 5.87 |
| CHEMBL609429 | — | — | 1 | 5.67 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL609689 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL609428 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL609688 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL609426 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL609685 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL609687 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL609427 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL609686 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL609430 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL609429 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 88750.0 | nM | 4.05 |