Assay Detail
Functional
CHEMBL896756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against NQO2 expressing human RT112 cells in presence of NRH cofactor by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RT-112 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of cryptolepine analogues as potential bioreducible anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.35 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 6.82 |
| CHEMBL609689 | — | — | 1 | 6.82 |
| CHEMBL609685 | — | — | 1 | 6.72 |
| CHEMBL609428 | — | — | 1 | 6.64 |
| CHEMBL609426 | — | — | 1 | 6.55 |
| CHEMBL609688 | — | — | 1 | 6.50 |
| CHEMBL609687 | — | — | 1 | 6.19 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | — | 1 | 6.10 |
| CHEMBL609427 | — | — | 1 | 6.09 |
| CHEMBL609686 | — | — | 1 | 5.97 |
| CHEMBL609430 | — | — | 1 | 5.96 |
| CHEMBL609429 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23330 | TRETAZICAR | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL609689 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL609685 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL609428 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL609426 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL609688 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL609687 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL609427 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL609686 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL609430 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL609429 | — | IC50 | = | 1670.0 | nM | 5.78 |