Assay Detail
Binding
CHEMBL896780
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Inhibition of human S1P expressed in CHOK1 cells
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Membrane-bound transcription factor site-1 protease (CHEMBL5916) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aminopyrrolidineamide inhibitors of site-1 protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.43 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391935 | — | — | 1 | 8.10 |
| CHEMBL233987 | — | — | 1 | 7.54 |
| CHEMBL233799 | — | — | 1 | 7.43 |
| CHEMBL233421 | — | — | 1 | 7.02 |
| CHEMBL233422 | — | — | 1 | 7.00 |
| CHEMBL233609 | — | — | 1 | 6.85 |
| CHEMBL233610 | — | — | 1 | 6.80 |
| CHEMBL233611 | — | — | 1 | 6.77 |
| CHEMBL394028 | — | — | 1 | 6.60 |
| CHEMBL393989 | — | — | 1 | 6.51 |
| CHEMBL232587 | — | — | 1 | 6.37 |
| CHEMBL232777 | — | — | 1 | 6.29 |
| CHEMBL231776 | — | — | 1 | 6.27 |
| CHEMBL233573 | — | — | 1 | 6.23 |
| CHEMBL233572 | — | — | 1 | 6.08 |
| CHEMBL394029 | — | — | 1 | 6.01 |
| CHEMBL232577 | — | — | 1 | 5.85 |
| CHEMBL393377 | — | — | 1 | 5.80 |
| CHEMBL232776 | — | — | 1 | 5.43 |
| CHEMBL233165 | — | — | 1 | 5.05 |
| CHEMBL233166 | — | — | 1 | 5.02 |
| CHEMBL232778 | — | — | 1 | - |
| CHEMBL397866 | — | — | 1 | - |
| CHEMBL233574 | — | — | 1 | - |
| CHEMBL233419 | — | — | 1 | - |
| CHEMBL233605 | — | — | 1 | - |
| CHEMBL233606 | — | — | 1 | - |
| CHEMBL233607 | — | — | 1 | - |
| CHEMBL233797 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391935 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL233987 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL233799 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL233421 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL233422 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL233609 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL233610 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL233611 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL394028 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL393989 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL232587 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL232777 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL231776 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL233573 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL233572 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL394029 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL232577 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL393377 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL232776 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL233165 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL233166 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL232778 | — | IC50 | > | 16000.0 | nM | - |
| CHEMBL397866 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL233574 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL233419 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL233605 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL233606 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL233607 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL233797 | — | IC50 | > | 30000.0 | nM | - |