Assay Detail
Functional
CHEMBL896865
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Agonist activity at human androgen receptor by luciferase reporter gene assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 8.18 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436784 | — | — | 1 | 9.70 |
| CHEMBL244896 | — | — | 1 | 8.59 |
| CHEMBL27769 | STANOLONE | 2.0 | 1 | 8.29 |
| CHEMBL467888 | LGD-2941 | 1.0 | 1 | 8.15 |
| CHEMBL2113293 | — | — | 1 | 8.08 |
| CHEMBL395992 | — | — | 1 | 7.92 |
| CHEMBL244895 | — | — | 1 | 7.89 |
| CHEMBL243252 | — | — | 1 | 7.68 |
| CHEMBL243251 | — | — | 1 | 7.32 |
| CHEMBL446191 | — | — | 1 | - |
| CHEMBL63560 | (R)-BICALUTAMIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436784 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL244896 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL27769 | STANOLONE | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL467888 | LGD-2941 | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL2113293 | — | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL395992 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL244895 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL243252 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL243251 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL446191 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL63560 | (R)-BICALUTAMIDE | EC50 | > | 10000.0 | nM | - |