Assay Detail
Functional
CHEMBL896867
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Antagonist activity at human androgen receptor by luciferase reporter gene assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.25 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446191 | — | — | 1 | 7.60 |
| CHEMBL63560 | (R)-BICALUTAMIDE | — | 1 | 6.89 |
| CHEMBL244895 | — | — | 1 | - |
| CHEMBL27769 | STANOLONE | 2.0 | 1 | - |
| CHEMBL436784 | — | — | 1 | - |
| CHEMBL2113293 | — | — | 1 | - |
| CHEMBL467888 | LGD-2941 | 1.0 | 1 | - |
| CHEMBL395992 | — | — | 1 | - |
| CHEMBL243252 | — | — | 1 | - |
| CHEMBL243251 | — | — | 1 | - |
| CHEMBL244896 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446191 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL63560 | (R)-BICALUTAMIDE | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL244895 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27769 | STANOLONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL436784 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2113293 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL467888 | LGD-2941 | IC50 | > | 10000.0 | nM | - |
| CHEMBL395992 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL243252 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL243251 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL244896 | — | IC50 | > | 10000.0 | nM | - |