Assay Detail
Binding
CHEMBL896869
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Binding affinity to human AR
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.75 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27769 | STANOLONE | 2.0 | 1 | 9.70 |
| CHEMBL467888 | LGD-2941 | 1.0 | 1 | 8.82 |
| CHEMBL436784 | — | — | 1 | 8.34 |
| CHEMBL2113293 | — | — | 1 | 8.12 |
| CHEMBL395992 | — | — | 1 | 8.00 |
| CHEMBL244896 | — | — | 1 | 7.72 |
| CHEMBL243251 | — | — | 1 | 7.37 |
| CHEMBL63560 | (R)-BICALUTAMIDE | — | 1 | 7.16 |
| CHEMBL243252 | — | — | 1 | 7.16 |
| CHEMBL244895 | — | — | 1 | 7.14 |
| CHEMBL446191 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27769 | STANOLONE | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL467888 | LGD-2941 | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL436784 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL2113293 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL395992 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL244896 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL243251 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL63560 | (R)-BICALUTAMIDE | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL243252 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL244895 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL446191 | — | Ki | = | 1700.0 | nM | 5.77 |