Assay Detail
Binding
CHEMBL897085
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Displacement of [3H]PGE2 from human recombinant EP1 receptor expressed in CHO cells
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP1 subtype (CHEMBL1811) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel, non-acidic 1,5-biaryl pyrrole EP1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 7.44 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL233768 | — | — | 1 | 8.80 |
| CHEMBL232340 | — | — | 1 | 8.60 |
| CHEMBL232117 | — | — | 1 | 8.60 |
| CHEMBL232341 | — | — | 1 | 8.60 |
| CHEMBL391286 | — | — | 1 | 8.40 |
| CHEMBL233137 | — | — | 1 | 8.40 |
| CHEMBL391287 | — | — | 1 | 8.30 |
| CHEMBL391026 | — | — | 1 | 8.30 |
| CHEMBL232932 | — | — | 1 | 8.10 |
| CHEMBL232543 | — | — | 1 | 8.10 |
| CHEMBL377852 | — | — | 1 | 8.10 |
| CHEMBL231723 | — | — | 1 | 8.00 |
| CHEMBL401023 | — | — | 1 | 7.90 |
| CHEMBL439381 | — | — | 1 | 7.80 |
| CHEMBL233138 | — | — | 1 | 7.80 |
| CHEMBL393187 | — | — | 1 | 7.70 |
| CHEMBL232930 | — | — | 1 | 7.70 |
| CHEMBL231722 | — | — | 1 | 7.70 |
| CHEMBL232544 | — | — | 1 | 7.60 |
| CHEMBL233140 | — | — | 1 | 7.60 |
| CHEMBL233975 | — | — | 1 | 7.60 |
| CHEMBL234176 | — | — | 1 | 7.60 |
| CHEMBL232931 | — | — | 1 | 7.50 |
| CHEMBL391931 | — | — | 1 | 7.40 |
| CHEMBL234181 | — | — | 1 | 7.40 |
| CHEMBL233160 | — | — | 1 | 7.40 |
| CHEMBL392047 | — | — | 1 | 7.40 |
| CHEMBL233565 | — | — | 1 | 7.40 |
| CHEMBL234174 | — | — | 1 | 7.30 |
| CHEMBL399800 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL233768 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL232340 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL232341 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL232117 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL391286 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL233137 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL391287 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL391026 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL232932 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL377852 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL232543 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL231723 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL401023 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL233138 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL439381 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL393187 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL231722 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL232930 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL232544 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL233140 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL233975 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL234176 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL232931 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL233565 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL392047 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL233160 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL391931 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL234181 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL234174 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL399800 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL393416 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL233159 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL233141 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL233146 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL233361 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL438126 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL232537 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL394173 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL234182 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL393743 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL232733 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL233772 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL232734 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL233359 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL234183 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL391228 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL391456 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL439388 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL391930 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL393374 | — | IC50 | = | 501.19 | nM | 6.30 |