Assay Detail
Functional
CHEMBL897350
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Antiviral activity against HIV1 assessed as reduction of virus-induced cytopathic effect in MT4 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.80 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 9.05 |
| CHEMBL234401 | — | — | 1 | 8.70 |
| CHEMBL234400 | — | — | 1 | 7.50 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.14 |
| CHEMBL393003 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL234401 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL234400 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL393003 | — | EC50 | = | 240.0 | nM | 6.62 |