Assay Detail
Functional
CHEMBL897354
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 with reverse transcriptase L100I mutation in CEM cells assessed as inhibition of virus-induced giant cell formation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.00 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL234401 | — | — | 1 | 8.22 |
| CHEMBL234400 | — | — | 1 | 7.31 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.24 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.70 |
| CHEMBL393003 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL234401 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL234400 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 57.3 | nM | 7.24 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 199.0 | nM | 6.70 |
| CHEMBL393003 | — | EC50 | = | 3100.0 | nM | 5.51 |