Assay Detail
Functional
CHEMBL897531
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Antiproliferative activity against human CEM cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel potent antimitotic heterocyclic ketones: synthesis, antiproliferative activity, and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.83 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.72 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 8.14 |
| CHEMBL230741 | — | — | 1 | 7.75 |
| CHEMBL391405 | — | — | 1 | 7.52 |
| CHEMBL236835 | — | — | 1 | 7.25 |
| CHEMBL236836 | — | — | 1 | 7.24 |
| CHEMBL237475 | — | — | 1 | 7.23 |
| CHEMBL216991 | — | — | 1 | 7.21 |
| CHEMBL237263 | — | — | 1 | 7.05 |
| CHEMBL238333 | — | — | 1 | 6.99 |
| CHEMBL439236 | — | — | 1 | 6.91 |
| CHEMBL237047 | — | — | 1 | 6.72 |
| CHEMBL395785 | — | — | 1 | 6.65 |
| CHEMBL238336 | — | — | 1 | 6.54 |
| CHEMBL235130 | — | — | 1 | 6.52 |
| CHEMBL237685 | — | — | 1 | 6.51 |
| CHEMBL235349 | — | — | 1 | 6.26 |
| CHEMBL232196 | — | — | 1 | 6.00 |
| CHEMBL238335 | — | — | 1 | 5.95 |
| CHEMBL237904 | — | — | 1 | 5.77 |
| CHEMBL391406 | — | — | 1 | 5.77 |
| CHEMBL238126 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL61 | PODOFILOX | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL230741 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL391405 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL236835 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL236836 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL237475 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL216991 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL237263 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL238333 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL439236 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL237047 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL395785 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL238336 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL235130 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL237685 | — | IC50 | = | 307.0 | nM | 6.51 |
| CHEMBL235349 | — | IC50 | = | 555.0 | nM | 6.26 |
| CHEMBL232196 | — | IC50 | = | 1012.0 | nM | 6.00 |
| CHEMBL238335 | — | IC50 | = | 1131.0 | nM | 5.95 |
| CHEMBL237904 | — | IC50 | = | 1693.0 | nM | 5.77 |
| CHEMBL391406 | — | IC50 | = | 1693.0 | nM | 5.77 |
| CHEMBL238126 | — | IC50 | = | 2370.0 | nM | 5.62 |