Assay Detail
Binding
CHEMBL897700
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Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
50
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
alpha,alpha-Cyclic aminoacids as useful scaffolds for the preparation of hNK(2) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 50 | 7.68 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL394889 | — | — | 1 | 9.40 |
| CHEMBL242631 | — | — | 1 | 9.20 |
| CHEMBL428203 | — | — | 1 | 9.10 |
| CHEMBL394878 | — | — | 2 | 9.00 |
| CHEMBL237097 | — | — | 1 | 8.90 |
| CHEMBL394420 | — | — | 1 | 8.90 |
| CHEMBL394418 | — | — | 2 | 8.90 |
| CHEMBL396827 | — | — | 1 | 8.80 |
| CHEMBL235574 | — | — | 2 | 8.80 |
| CHEMBL398028 | — | — | 1 | 8.70 |
| CHEMBL394419 | — | — | 2 | 8.70 |
| CHEMBL235353 | — | — | 1 | 8.70 |
| CHEMBL237048 | — | — | 1 | 8.60 |
| CHEMBL235431 | — | — | 1 | 8.40 |
| CHEMBL237304 | — | — | 1 | 8.40 |
| CHEMBL397576 | — | — | 1 | 8.20 |
| CHEMBL394648 | — | — | 1 | 8.10 |
| CHEMBL3143848 | — | — | 1 | 7.90 |
| CHEMBL236250 | — | — | 1 | 7.90 |
| CHEMBL237303 | — | — | 1 | 7.70 |
| CHEMBL236890 | — | — | 1 | 7.70 |
| CHEMBL437777 | — | — | 1 | 7.60 |
| CHEMBL400209 | — | — | 1 | 7.50 |
| CHEMBL428905 | — | — | 1 | 7.40 |
| CHEMBL237517 | — | — | 1 | 7.30 |
| CHEMBL238392 | — | — | 1 | 7.30 |
| CHEMBL398982 | — | — | 1 | 7.30 |
| CHEMBL429631 | — | — | 1 | 7.20 |
| CHEMBL238181 | — | — | 1 | 7.15 |
| CHEMBL237081 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL394889 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL242631 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL428203 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL394878 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL237097 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL394420 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL394418 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL396827 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL235574 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL398028 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL394419 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL235353 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL237048 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL237304 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL235431 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL394418 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL397576 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL394648 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL3143848 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL236250 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL236890 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL237303 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL437777 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL400209 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL235574 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL428905 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL238392 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL398982 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL237517 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL429631 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL238181 | — | Ki | = | 70.79 | nM | 7.15 |
| CHEMBL237516 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL394419 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL236659 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL236873 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL428906 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL237082 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL237081 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL236458 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL236874 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL236661 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL429452 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL392523 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL391710 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL3143849 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL236248 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL391696 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL394878 | — | Ki | < | 100.0 | nM | - |
| CHEMBL236459 | — | Ki | < | 1000.0 | nM | - |
| CHEMBL236660 | — | Ki | < | 10000.0 | nM | - |