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Assay Detail

CHEMBL897776

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human DLD1 cells assessed as cell viability after 48 hrs
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type DLD-1
Confidence 1 — Organism
Curated By Autocuration

Target

DLD-1 (CHEMBL614285)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and structure-activity relationship study of cytotoxic germanicane- and lupane-type 3beta-O-monodesmosidic saponins starting from betulin.
Thibeault D, Gauthier C, Legault J, Bouchard J, Dufour P, Pichette A.
Bioorg Med Chem (2007) 15 : 6144 -6157
PubMed 17614290 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 4.68 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL237068 1 5.00
CHEMBL237890 1 4.82
CHEMBL396650 1 4.75
CHEMBL312687 1 4.70
CHEMBL268134 1 4.40
CHEMBL413019 1 4.40
CHEMBL238131 1 -
CHEMBL268370 1 -
CHEMBL238130 1 -
CHEMBL437010 1 -
CHEMBL396654 1 -
CHEMBL396653 1 -
CHEMBL238129 1 -
CHEMBL439039 1 -
CHEMBL237908 1 -
CHEMBL496855 ALLOBETULIN 1 -
CHEMBL396425 1 -
CHEMBL397147 1 -
CHEMBL397146 1 -
CHEMBL396877 1 -
CHEMBL522595 1 -
CHEMBL413020 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL237068 IC50 = 10100.0 nM 5.00
CHEMBL237890 IC50 = 15000.0 nM 4.82
CHEMBL396650 IC50 = 18000.0 nM 4.75
CHEMBL312687 IC50 = 20000.0 nM 4.70
CHEMBL268134 IC50 = 40000.0 nM 4.40
CHEMBL413019 IC50 = 40000.0 nM 4.40
CHEMBL238131 IC50 > 75000.0 nM -
CHEMBL268370 IC50 > 75000.0 nM -
CHEMBL238130 IC50 > 75000.0 nM -
CHEMBL437010 IC50 > 75000.0 nM -
CHEMBL396654 IC50 > 75000.0 nM -
CHEMBL396653 IC50 > 75000.0 nM -
CHEMBL238129 IC50 > 75000.0 nM -
CHEMBL439039 IC50 > 75000.0 nM -
CHEMBL237908 IC50 > 75000.0 nM -
CHEMBL496855 ALLOBETULIN IC50 > 75000.0 nM -
CHEMBL396425 IC50 > 75000.0 nM -
CHEMBL397147 IC50 > 75000.0 nM -
CHEMBL397146 IC50 > 75000.0 nM -
CHEMBL396877 IC50 > 75000.0 nM -
CHEMBL522595 IC50 > 75000.0 nM -
CHEMBL413020 IC50 > 75000.0 nM -