Assay Detail
Functional
CHEMBL897791
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay
22
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Non-steroidal glucocorticoid agonists: the discovery of aryl pyrazoles as A-ring mimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 8.17 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235208 | — | — | 2 | 9.34 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 9.00 |
| CHEMBL394168 | — | — | 1 | 8.78 |
| CHEMBL237973 | — | — | 2 | 8.52 |
| CHEMBL234988 | — | — | 2 | 8.43 |
| CHEMBL393011 | — | — | 2 | 8.35 |
| CHEMBL236947 | — | — | 2 | 8.23 |
| CHEMBL235205 | — | — | 2 | 8.07 |
| CHEMBL392319 | — | — | 2 | 7.31 |
| CHEMBL391874 | — | — | 4 | - |
| CHEMBL236320 | — | — | 1 | - |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235208 | — | IC50 | = | 0.4571 | nM | 9.34 |
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL394168 | — | IC50 | = | 1.66 | nM | 8.78 |
| CHEMBL237973 | — | IC50 | = | 3.02 | nM | 8.52 |
| CHEMBL237973 | — | IC50 | = | 3.631 | nM | 8.44 |
| CHEMBL234988 | — | IC50 | = | 3.715 | nM | 8.43 |
| CHEMBL393011 | — | IC50 | = | 4.467 | nM | 8.35 |
| CHEMBL236947 | — | IC50 | = | 5.888 | nM | 8.23 |
| CHEMBL393011 | — | IC50 | = | 6.457 | nM | 8.19 |
| CHEMBL235205 | — | IC50 | = | 8.511 | nM | 8.07 |
| CHEMBL234988 | — | IC50 | = | 13.18 | nM | 7.88 |
| CHEMBL236947 | — | IC50 | = | 16.98 | nM | 7.77 |
| CHEMBL235208 | — | IC50 | = | 17.78 | nM | 7.75 |
| CHEMBL235205 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL392319 | — | IC50 | = | 48.98 | nM | 7.31 |
| CHEMBL392319 | — | IC50 | = | 83.18 | nM | 7.08 |
| CHEMBL391874 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL391874 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL391874 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL391874 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL236320 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL1276308 | MIFEPRISTONE | IC50 | < | 1000.0 | nM | - |