Assay Detail
Functional
CHEMBL897792
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Agonist activity at glucocorticoid receptor in human A549 cells by MMTV transactivation assay
22
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Non-steroidal glucocorticoid agonists: the discovery of aryl pyrazoles as A-ring mimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 7.78 | 8.92 |
| Log EC50 | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235208 | — | — | 2 | 8.92 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 8.27 |
| CHEMBL394168 | — | — | 1 | 8.25 |
| CHEMBL237973 | — | — | 2 | 8.11 |
| CHEMBL393011 | — | — | 2 | 7.91 |
| CHEMBL234988 | — | — | 2 | 7.82 |
| CHEMBL236947 | — | — | 2 | 7.74 |
| CHEMBL235205 | — | — | 2 | 7.02 |
| CHEMBL236320 | — | — | 1 | - |
| CHEMBL391874 | — | — | 4 | - |
| CHEMBL392319 | — | — | 2 | - |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235208 | — | EC50 | = | 1.202 | nM | 8.92 |
| CHEMBL384467 | DEXAMETHASONE | EC50 | = | 5.37 | nM | 8.27 |
| CHEMBL394168 | — | EC50 | = | 5.623 | nM | 8.25 |
| CHEMBL237973 | — | EC50 | = | 7.762 | nM | 8.11 |
| CHEMBL237973 | — | EC50 | = | 10.72 | nM | 7.97 |
| CHEMBL393011 | — | EC50 | = | 12.3 | nM | 7.91 |
| CHEMBL393011 | — | EC50 | = | 14.45 | nM | 7.84 |
| CHEMBL234988 | — | EC50 | = | 15.14 | nM | 7.82 |
| CHEMBL235208 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL234988 | — | EC50 | = | 17.38 | nM | 7.76 |
| CHEMBL236947 | — | EC50 | = | 18.2 | nM | 7.74 |
| CHEMBL235205 | — | EC50 | = | 95.5 | nM | 7.02 |
| CHEMBL235205 | — | EC50 | = | 151.36 | nM | 6.82 |
| CHEMBL236947 | — | EC50 | = | 181.97 | nM | 6.74 |
| CHEMBL392319 | — | EC50 | < | 1000.0 | nM | - |
| CHEMBL392319 | — | EC50 | < | 1000.0 | nM | - |
| CHEMBL1276308 | MIFEPRISTONE | EC50 | < | 1000.0 | nM | - |
| CHEMBL391874 | — | Log EC50 | - | — | - | |
| CHEMBL391874 | — | Log EC50 | - | — | - | |
| CHEMBL391874 | — | Log EC50 | - | — | - | |
| CHEMBL391874 | — | EC50 | < | 1000.0 | nM | - |
| CHEMBL236320 | — | Log EC50 | - | — | - |