Assay Detail
Binding
CHEMBL897804
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Binding affinity to human histamine H3 receptor
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 7.82 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129542 | JNJ-5207852 | — | 1 | 9.22 |
| CHEMBL235614 | — | — | 1 | 9.15 |
| CHEMBL237087 | — | — | 1 | 8.89 |
| CHEMBL393036 | — | — | 1 | 8.77 |
| CHEMBL194092 | — | — | 1 | 8.68 |
| CHEMBL397575 | — | — | 1 | 8.52 |
| CHEMBL236674 | — | — | 1 | 8.52 |
| CHEMBL235824 | — | — | 1 | 8.40 |
| CHEMBL238143 | — | — | 1 | 8.33 |
| CHEMBL238141 | — | — | 1 | 8.28 |
| CHEMBL237317 | — | — | 1 | 8.27 |
| CHEMBL428024 | — | — | 1 | 8.24 |
| CHEMBL391074 | — | — | 1 | 8.22 |
| CHEMBL397577 | — | — | 1 | 8.22 |
| CHEMBL237512 | — | — | 1 | 8.21 |
| CHEMBL236252 | — | — | 1 | 8.15 |
| CHEMBL236475 | — | — | 1 | 8.15 |
| CHEMBL236675 | — | — | 1 | 8.14 |
| CHEMBL237513 | — | — | 1 | 8.01 |
| CHEMBL236010 | — | — | 1 | 8.01 |
| CHEMBL391947 | — | — | 1 | 7.96 |
| CHEMBL236047 | — | — | 1 | 7.96 |
| CHEMBL236046 | — | — | 1 | 7.96 |
| CHEMBL236676 | — | — | 1 | 7.89 |
| CHEMBL237319 | — | — | 1 | 7.89 |
| CHEMBL237747 | — | — | 1 | 7.85 |
| CHEMBL442080 | — | — | 1 | 7.77 |
| CHEMBL235814 | — | — | 1 | 7.77 |
| CHEMBL441137 | — | — | 1 | 7.51 |
| CHEMBL238182 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129542 | JNJ-5207852 | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL235614 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL237087 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL393036 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL194092 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL397575 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL236674 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL235824 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL238143 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL238141 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL237317 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL428024 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL391074 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL397577 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL237512 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL236252 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL236475 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL236675 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL237513 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL236010 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL391947 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL236047 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL236046 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL236676 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL237319 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL237747 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL235814 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL442080 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL441137 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL238182 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL398981 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL235794 | — | Ki | = | 423.0 | nM | 6.37 |
| CHEMBL237514 | — | Ki | = | 864.0 | nM | 6.06 |
| CHEMBL393009 | — | Ki | = | 1867.0 | nM | 5.73 |
| CHEMBL41 | FLUOXETINE | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL237521 | — | Ki | = | 9000.0 | nM | 5.05 |