Assay Detail
Functional
CHEMBL897805
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human histamine H3 receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 8.32 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237512 | — | — | 1 | 9.10 |
| CHEMBL397577 | — | — | 1 | 8.78 |
| CHEMBL393036 | — | — | 1 | 8.61 |
| CHEMBL397575 | — | — | 1 | 8.58 |
| CHEMBL236674 | — | — | 1 | 8.45 |
| CHEMBL428024 | — | — | 1 | 8.14 |
| CHEMBL391074 | — | — | 1 | 8.12 |
| CHEMBL236475 | — | — | 1 | 7.97 |
| CHEMBL236046 | — | — | 1 | 7.95 |
| CHEMBL236675 | — | — | 1 | 7.90 |
| CHEMBL236676 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237512 | — | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL397577 | — | Kd | = | 1.66 | nM | 8.78 |
| CHEMBL393036 | — | Kd | = | 2.455 | nM | 8.61 |
| CHEMBL397575 | — | Kd | = | 2.63 | nM | 8.58 |
| CHEMBL236674 | — | Kd | = | 3.548 | nM | 8.45 |
| CHEMBL428024 | — | Kd | = | 7.244 | nM | 8.14 |
| CHEMBL391074 | — | Kd | = | 7.586 | nM | 8.12 |
| CHEMBL236475 | — | Kd | = | 10.72 | nM | 7.97 |
| CHEMBL236046 | — | Kd | = | 11.22 | nM | 7.95 |
| CHEMBL236675 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL236676 | — | Kd | = | 12.88 | nM | 7.89 |