Assay Detail
Binding
CHEMBL897945
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Inhibition of rabbit 15-lipoxygenase in presence of linoleic acid
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL4358) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: highly potent against human enzyme within a cellular environment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.12 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235920 | — | — | 1 | 8.52 |
| CHEMBL399821 | — | — | 1 | 8.22 |
| CHEMBL398582 | — | — | 1 | 8.00 |
| CHEMBL235251 | — | — | 1 | 7.96 |
| CHEMBL392977 | — | — | 1 | 7.85 |
| CHEMBL235069 | — | — | 1 | 7.85 |
| CHEMBL401221 | — | — | 1 | 7.68 |
| CHEMBL401246 | — | — | 1 | 7.51 |
| CHEMBL236827 | — | — | 1 | 7.48 |
| CHEMBL391659 | — | — | 1 | 7.44 |
| CHEMBL235250 | — | — | 1 | 7.42 |
| CHEMBL236354 | — | — | 1 | 7.35 |
| CHEMBL391039 | — | — | 1 | 7.28 |
| CHEMBL237828 | — | — | 1 | 7.26 |
| CHEMBL237017 | — | — | 1 | 7.23 |
| CHEMBL236828 | — | — | 1 | 7.14 |
| CHEMBL401456 | — | — | 1 | 7.10 |
| CHEMBL401220 | — | — | 1 | 7.09 |
| CHEMBL235030 | — | — | 1 | 7.08 |
| CHEMBL237404 | — | — | 1 | 7.06 |
| CHEMBL262582 | — | — | 1 | 7.04 |
| CHEMBL399197 | — | — | 1 | 7.00 |
| CHEMBL391038 | — | — | 1 | 6.85 |
| CHEMBL235029 | — | — | 1 | 6.67 |
| CHEMBL235031 | — | — | 1 | 6.57 |
| CHEMBL235275 | — | — | 1 | 6.44 |
| CHEMBL393108 | — | — | 1 | 6.25 |
| CHEMBL392570 | — | — | 1 | 6.14 |
| CHEMBL237409 | — | — | 1 | 6.01 |
| CHEMBL237024 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235920 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL399821 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL398582 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL235251 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL392977 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL235069 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL401221 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL401246 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL236827 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL391659 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL235250 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL236354 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL391039 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL237828 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL237017 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL236828 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL401456 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL401220 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL235030 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL237404 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL262582 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL399197 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL391038 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL235029 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL235031 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL235275 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL393108 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL392570 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL237409 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL237024 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL237217 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL237401 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL237209 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL237020 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL237019 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL237018 | — | IC50 | > | 10000.0 | nM | - |