Assay Detail
Binding
CHEMBL897946
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Inhibition of rabbit 15-lipoxygenase in presence of arachidonic acid
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL4358) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: highly potent against human enzyme within a cellular environment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.54 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399821 | — | — | 1 | 7.89 |
| CHEMBL392977 | — | — | 1 | 7.30 |
| CHEMBL235069 | — | — | 1 | 7.30 |
| CHEMBL235920 | — | — | 1 | 7.12 |
| CHEMBL401456 | — | — | 1 | 7.08 |
| CHEMBL235251 | — | — | 1 | 7.08 |
| CHEMBL391659 | — | — | 1 | 6.88 |
| CHEMBL236354 | — | — | 1 | 6.88 |
| CHEMBL398582 | — | — | 1 | 6.88 |
| CHEMBL236827 | — | — | 1 | 6.79 |
| CHEMBL401246 | — | — | 1 | 6.73 |
| CHEMBL237017 | — | — | 1 | 6.58 |
| CHEMBL236828 | — | — | 1 | 6.43 |
| CHEMBL235250 | — | — | 1 | 6.43 |
| CHEMBL237828 | — | — | 1 | 6.42 |
| CHEMBL391039 | — | — | 1 | 6.40 |
| CHEMBL401220 | — | — | 1 | 6.28 |
| CHEMBL262582 | — | — | 1 | 6.19 |
| CHEMBL235030 | — | — | 1 | 6.14 |
| CHEMBL391038 | — | — | 1 | 6.04 |
| CHEMBL399197 | — | — | 1 | 5.96 |
| CHEMBL401221 | — | — | 1 | 5.96 |
| CHEMBL235031 | — | — | 1 | 5.62 |
| CHEMBL235275 | — | — | 1 | 5.55 |
| CHEMBL235029 | — | — | 1 | 5.46 |
| CHEMBL237409 | — | — | 1 | - |
| CHEMBL237404 | — | — | 1 | - |
| CHEMBL237024 | — | — | 1 | - |
| CHEMBL237401 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399821 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL392977 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL235069 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL235920 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL401456 | — | IC50 | = | 82.2 | nM | 7.08 |
| CHEMBL235251 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL391659 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL236354 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL398582 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL236827 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL401246 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL237017 | — | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL236828 | — | IC50 | = | 372.0 | nM | 6.43 |
| CHEMBL235250 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL237828 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL391039 | — | IC50 | = | 396.0 | nM | 6.40 |
| CHEMBL401220 | — | IC50 | = | 531.0 | nM | 6.28 |
| CHEMBL262582 | — | IC50 | = | 646.0 | nM | 6.19 |
| CHEMBL235030 | — | IC50 | = | 719.0 | nM | 6.14 |
| CHEMBL391038 | — | IC50 | = | 914.0 | nM | 6.04 |
| CHEMBL399197 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL401221 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL235031 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL235275 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL235029 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL237409 | — | IC50 | = | 5322000.0 | nM | - |
| CHEMBL237404 | — | IC50 | = | 3211000.0 | nM | - |
| CHEMBL237024 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL237401 | — | IC50 | > | 10000.0 | nM | - |