Assay Detail
Binding
CHEMBL897957
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Inhibition of human recombinant 15-lipoxygenase over-expressed in CHO cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15B (CHEMBL2457) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: highly potent against human enzyme within a cellular environment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.48 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235920 | — | — | 1 | 7.29 |
| CHEMBL399821 | — | — | 1 | 6.83 |
| CHEMBL392977 | — | — | 1 | 6.40 |
| CHEMBL391659 | — | — | 1 | 6.36 |
| CHEMBL401246 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235920 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL399821 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL392977 | — | IC50 | = | 402.0 | nM | 6.40 |
| CHEMBL391659 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL401246 | — | IC50 | = | 3130.0 | nM | 5.50 |