Assay Detail
Binding
CHEMBL898017
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Inhibition of EGFR kinase autophosphorylation in A431 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.52 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220037 | — | — | 1 | 7.52 |
| CHEMBL200381 | — | — | 1 | - |
| CHEMBL236384 | — | — | 1 | - |
| CHEMBL236383 | — | — | 1 | - |
| CHEMBL446633 | — | — | 1 | - |
| CHEMBL238323 | — | — | 1 | - |
| CHEMBL393707 | — | — | 1 | - |
| CHEMBL238322 | — | — | 1 | - |
| CHEMBL238273 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220037 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL200381 | — | IC50 | < | 5000.0 | nM | - |
| CHEMBL236384 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL236383 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL446633 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL238323 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL393707 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL238322 | — | IC50 | < | 5000.0 | nM | - |
| CHEMBL238273 | — | IC50 | > | 40000.0 | nM | - |