Assay Detail
Functional
CHEMBL898019
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Inhibition of LPS-induced TNFalpha production in human blood
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.24 | 5.48 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220037 | — | — | 1 | 5.48 |
| CHEMBL236383 | — | — | 1 | 5.38 |
| CHEMBL236384 | — | — | 1 | 5.35 |
| CHEMBL238273 | — | — | 1 | 5.35 |
| CHEMBL393707 | — | — | 1 | 5.33 |
| CHEMBL238323 | — | — | 1 | 5.11 |
| CHEMBL238322 | — | — | 1 | 4.70 |
| CHEMBL200381 | — | — | 1 | - |
| CHEMBL391358 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220037 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL236383 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL236384 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL238273 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL393707 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL238323 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL238322 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL200381 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL391358 | — | Activity | - | — | - |