Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL898037

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of P-p38 kinase in human monocytes
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

MAP kinase p38 (CHEMBL2094115)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles.
Kaila N, Green N, Li HQ, Hu Y, Janz K, Gavrin LK, Thomason J, Tam S, Powell D, Cuozzo J, Hall JP, Telliez JB, Hsu S, Nickerson-Nutter C, Wang Q, Lin LL.
Bioorg Med Chem (2007) 15 : 6425 -6442
PubMed 17664070 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.68 5.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL220037 1 5.68

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL220037 IC50 = 2110.0 nM 5.68