Assay Detail
Binding
CHEMBL898044
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Inhibition of human plasma BuChE activity
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.16 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392577 | — | — | 1 | 8.46 |
| CHEMBL241115 | — | — | 1 | 7.55 |
| CHEMBL240899 | — | — | 1 | 7.06 |
| CHEMBL241114 | — | — | 1 | 7.05 |
| CHEMBL391727 | — | — | 1 | 6.66 |
| CHEMBL394755 | — | — | 1 | 6.66 |
| CHEMBL240261 | — | — | 1 | 6.40 |
| CHEMBL240900 | — | — | 1 | 6.33 |
| CHEMBL240045 | — | — | 1 | 6.25 |
| CHEMBL239616 | — | — | 1 | 6.22 |
| CHEMBL394753 | — | — | 1 | 6.21 |
| CHEMBL239834 | — | — | 1 | 6.09 |
| CHEMBL239617 | — | — | 1 | 5.89 |
| CHEMBL239618 | — | — | 1 | 5.82 |
| CHEMBL240469 | — | — | 1 | 5.77 |
| CHEMBL240262 | — | — | 1 | 5.77 |
| CHEMBL239401 | — | — | 1 | 5.72 |
| CHEMBL397100 | — | — | 1 | 5.60 |
| CHEMBL241558 | — | — | 1 | 5.57 |
| CHEMBL397099 | — | — | 1 | 5.51 |
| CHEMBL239400 | — | — | 1 | 5.24 |
| CHEMBL240047 | — | — | 1 | 5.21 |
| CHEMBL397101 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392577 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL241115 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL240899 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL241114 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL391727 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL394755 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL240261 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL240900 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL240045 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL239616 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL394753 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL239834 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL239617 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL239618 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL240469 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL240262 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL239401 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL397100 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL241558 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL397099 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL239400 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL240047 | — | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL397101 | — | Ki | = | 23000.0 | nM | 4.64 |