Assay Detail
Functional
CHEMBL898093
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Metabotropic glutamate receptor 5 (CHEMBL2564) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.70 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66654 | — | — | 1 | 9.70 |
| CHEMBL232188 | — | — | 1 | 9.10 |
| CHEMBL396135 | — | — | 1 | 8.85 |
| CHEMBL232189 | — | — | 1 | 8.80 |
| CHEMBL231790 | — | — | 1 | 8.70 |
| CHEMBL231788 | — | — | 1 | 8.70 |
| CHEMBL233417 | — | — | 1 | 8.62 |
| CHEMBL244796 | — | — | 1 | 8.11 |
| CHEMBL396177 | — | — | 1 | 7.89 |
| CHEMBL233358 | — | — | 1 | 7.77 |
| CHEMBL233418 | — | — | 1 | 7.64 |
| CHEMBL233615 | — | — | 1 | 7.14 |
| CHEMBL396415 | — | — | 1 | 7.12 |
| CHEMBL233616 | — | — | 1 | 7.09 |
| CHEMBL233617 | — | — | 1 | 6.51 |
| CHEMBL233618 | — | — | 1 | 6.44 |
| CHEMBL267839 | — | — | 1 | 6.37 |
| CHEMBL231763 | — | — | 1 | 6.29 |
| CHEMBL394876 | — | — | 1 | 6.07 |
| CHEMBL233807 | — | — | 1 | 5.96 |
| CHEMBL231764 | — | — | 1 | 5.75 |
| CHEMBL231765 | — | — | 1 | 5.47 |
| CHEMBL231991 | — | — | 1 | 5.38 |
| CHEMBL233370 | — | — | 1 | 5.32 |
| CHEMBL231985 | — | — | 1 | 5.24 |
| CHEMBL231986 | — | — | 1 | 5.06 |
| CHEMBL244418 | — | — | 1 | 5.05 |
| CHEMBL434585 | — | — | 1 | 5.01 |
| CHEMBL413487 | — | — | 1 | 4.92 |
| CHEMBL231987 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66654 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL232188 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL396135 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL232189 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL231790 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL231788 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL233417 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL244796 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL396177 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL233358 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL233418 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL233615 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL396415 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL233616 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL233617 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL233618 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL267839 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL231763 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL394876 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL233807 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL231764 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL231765 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL231991 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL233370 | — | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL231985 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL231986 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL244418 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL434585 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL413487 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL231987 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL396134 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL231988 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL395899 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL232184 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL231989 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL232187 | — | IC50 | > | 10000.0 | nM | - |