Assay Detail
Functional
CHEMBL898136
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Antiproliferative activity against human cisplatin-resistant IGROV1/Pt1 cells with p53 mutation after 72 hrs
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IGROV-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.70 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL238378 | — | — | 1 | 6.41 |
| CHEMBL442016 | ADAROTENE | — | 1 | 6.40 |
| CHEMBL238173 | — | — | 1 | 6.34 |
| CHEMBL236672 | — | — | 1 | 6.32 |
| CHEMBL392719 | — | — | 1 | 6.01 |
| CHEMBL429990 | — | — | 1 | 5.98 |
| CHEMBL236657 | — | — | 1 | 5.84 |
| CHEMBL238379 | — | — | 1 | 5.62 |
| CHEMBL235172 | — | — | 1 | 5.57 |
| CHEMBL428902 | — | — | 1 | 5.54 |
| CHEMBL236673 | — | — | 1 | 5.32 |
| CHEMBL238372 | — | — | 1 | 5.32 |
| CHEMBL236240 | — | — | 1 | 4.66 |
| CHEMBL236884 | — | — | 1 | 4.47 |
| CHEMBL238172 | — | — | 1 | - |
| CHEMBL372221 | — | — | 1 | - |
| CHEMBL393995 | — | — | 1 | - |
| CHEMBL393996 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL238378 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL442016 | ADAROTENE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL238173 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL236672 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL392719 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL429990 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL236657 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL238379 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL235172 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL428902 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL236673 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL238372 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL236240 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL236884 | — | IC50 | = | 34100.0 | nM | 4.47 |
| CHEMBL238172 | — | IC50 | - | — | - | |
| CHEMBL372221 | — | IC50 | - | — | - | |
| CHEMBL393995 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL393996 | — | IC50 | > | 20000.0 | nM | - |