Assay Detail
Binding
CHEMBL898176
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Inhibition of COX1 in human whole blood after 15 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.09 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396182 | — | — | 1 | 5.72 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.16 |
| CHEMBL398087 | — | — | 1 | 4.97 |
| CHEMBL236433 | — | — | 1 | 4.89 |
| CHEMBL236238 | — | — | 1 | 4.70 |
| CHEMBL235786 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396182 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL398087 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL236433 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL236238 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL235786 | — | IC50 | > | 100000.0 | nM | - |