Assay Detail
Functional
CHEMBL898199
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Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 72 hrs by ribonuclease protection assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and HCV inhibitory properties of 9-deaza- and 7,9-dideaza-7-oxa-2'-C-methyladenosine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.76 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL236207 | BETA-2'-C-METHYL-7-DEAZA-ADENOSINE | — | 1 | 6.96 |
| CHEMBL73809 | — | — | 1 | 6.70 |
| CHEMBL393820 | VALOPICITABINE | 2.0 | 1 | 5.82 |
| CHEMBL236435 | — | — | 1 | 5.09 |
| CHEMBL393488 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL236207 | BETA-2'-C-METHYL-7-DEAZA-ADENOSINE | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL73809 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL393820 | VALOPICITABINE | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL236435 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL393488 | — | EC50 | = | 59700.0 | nM | 4.22 |