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Assay Detail

CHEMBL898226

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Binding
Inhibition of human thyroid hormone receptor beta 1
ChEMBL ↗
84
Total Activities
82
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Thyroid hormone receptor beta (CHEMBL1947) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

QSAR study of selective ligands for the thyroid hormone receptor beta.
Liu H, Gramatica P.
Bioorg Med Chem (2007) 15 : 5251 -5261
PubMed 17524652 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 84 8.00 10.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL291053 THYROPROPIC ACID 2.0 1 10.72
CHEMBL289343 — — 1 10.60
CHEMBL41632 TIRATRICOL 3.0 1 10.32
CHEMBL124126 — — 1 10.25
CHEMBL39174 — — 1 10.02
CHEMBL235173 — — 1 9.96
CHEMBL124205 — — 2 9.95
CHEMBL418432 — — 1 9.82
CHEMBL413699 — — 1 9.71
CHEMBL1544 LIOTHYRONINE 4.0 1 9.59
CHEMBL126693 — — 1 9.55
CHEMBL125728 — — 1 9.44
CHEMBL392925 — — 1 9.33
CHEMBL235609 — — 1 9.21
CHEMBL237096 — — 1 9.19
CHEMBL125946 — — 1 9.11
CHEMBL236436 — — 1 9.11
CHEMBL125317 — — 1 9.06
CHEMBL442243 — — 1 9.03
CHEMBL237529 — — 1 8.99
CHEMBL41036 — — 1 8.96
CHEMBL235384 — — 1 8.96
CHEMBL124039 — — 1 8.95
CHEMBL340158 — — 1 8.89
CHEMBL333650 — — 1 8.89
CHEMBL125242 — — 2 8.76
CHEMBL124318 — — 1 8.75
CHEMBL124819 — — 1 8.70
CHEMBL289965 — — 1 8.68
CHEMBL235788 — — 1 8.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL291053 THYROPROPIC ACID IC50 = 0.01905 nM 10.72
CHEMBL289343 — IC50 = 0.02512 nM 10.60
CHEMBL41632 TIRATRICOL IC50 = 0.04786 nM 10.32
CHEMBL124126 — IC50 = 0.05623 nM 10.25
CHEMBL39174 — IC50 = 0.0955 nM 10.02
CHEMBL235173 — IC50 = 0.1096 nM 9.96
CHEMBL124205 — IC50 = 0.1122 nM 9.95
CHEMBL418432 — IC50 = 0.1514 nM 9.82
CHEMBL124205 — IC50 = 0.166 nM 9.78
CHEMBL413699 — IC50 = 0.195 nM 9.71
CHEMBL1544 LIOTHYRONINE IC50 = 0.257 nM 9.59
CHEMBL126693 — IC50 = 0.2818 nM 9.55
CHEMBL125728 — IC50 = 0.3631 nM 9.44
CHEMBL392925 — IC50 = 0.4677 nM 9.33
CHEMBL235609 — IC50 = 0.6166 nM 9.21
CHEMBL237096 — IC50 = 0.6457 nM 9.19
CHEMBL125946 — IC50 = 0.7762 nM 9.11
CHEMBL236436 — IC50 = 0.7762 nM 9.11
CHEMBL125317 — IC50 = 0.871 nM 9.06
CHEMBL442243 — IC50 = 0.9333 nM 9.03
CHEMBL237529 — IC50 = 1.023 nM 8.99
CHEMBL235384 — IC50 = 1.096 nM 8.96
CHEMBL41036 — IC50 = 1.096 nM 8.96
CHEMBL124039 — IC50 = 1.122 nM 8.95
CHEMBL333650 — IC50 = 1.288 nM 8.89
CHEMBL340158 — IC50 = 1.288 nM 8.89
CHEMBL125242 — IC50 = 1.738 nM 8.76
CHEMBL124318 — IC50 = 1.778 nM 8.75
CHEMBL124819 — IC50 = 1.995 nM 8.70
CHEMBL289965 — IC50 = 2.089 nM 8.68
CHEMBL235788 — IC50 = 2.884 nM 8.54
CHEMBL236438 — IC50 = 3.388 nM 8.47
CHEMBL235835 — IC50 = 3.467 nM 8.46
CHEMBL393489 — IC50 = 3.981 nM 8.40
CHEMBL391945 — IC50 = 4.169 nM 8.38
CHEMBL381937 — IC50 = 4.266 nM 8.37
CHEMBL237958 — IC50 = 4.786 nM 8.32
CHEMBL125242 — IC50 = 5.248 nM 8.28
CHEMBL235607 — IC50 = 6.026 nM 8.22
CHEMBL235165 — IC50 = 6.026 nM 8.22
CHEMBL235816 — IC50 = 6.761 nM 8.17
CHEMBL235383 — IC50 = 7.586 nM 8.12
CHEMBL396304 — IC50 = 7.762 nM 8.11
CHEMBL238178 — IC50 = 8.511 nM 8.07
CHEMBL394176 — IC50 = 9.55 nM 8.02
CHEMBL394644 — IC50 = 10.96 nM 7.96
CHEMBL204609 — IC50 = 15.85 nM 7.80
CHEMBL429078 — IC50 = 18.2 nM 7.74
CHEMBL202940 — IC50 = 18.2 nM 7.74
CHEMBL40738 — IC50 = 20.89 nM 7.68