Compound Detail
CHEMBL235173
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL235173 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RNNRJYLAQGIPJH-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
567.2
MW (Da)
4.47
ALogP
4
HBA
3
HBD
92.8
PSA (Ų)
0.45
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thyroid hormone receptor beta CHEMBL1947 | IC50 | 9.96 | 9.96 | 0.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thyroid hormone receptor beta | IC50 | = | 0.1096 | nM | 9.96 | Inhibition of human thyroid hormone receptor beta 1 | 17524652 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3336030 | 10.1021/jm00396a008 | Thyroid hormone receptor beta | 4 |
| 195056 | 10.1021/jm00217a001 | Unchecked | 4 |
| 195056 | 10.1021/jm00217a001 | Thyroxine-binding globulin | 2 |
| 195056 | 10.1021/jm00217a001 | Rattus norvegicus | 2 |
| 3336030 | 10.1021/jm00396a008 | No relevant target | 1 |
| 17524652 | 10.1016/j.bmc.2007.05.016 | Thyroid hormone receptor beta | 1 |
Data from ChEMBL 36 via Core Engine