Assay Detail
Binding
CHEMBL898302
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Inhibition of human low molecular weight Protein-tyrosine phosphatase IF2
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Low molecular weight phosphotyrosine protein phosphatase (CHEMBL4903) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.60 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235595 | — | — | 1 | 5.25 |
| CHEMBL393606 | — | — | 1 | 4.89 |
| CHEMBL235596 | — | — | 1 | 4.74 |
| CHEMBL235805 | — | — | 1 | 4.58 |
| CHEMBL397791 | — | — | 1 | 4.07 |
| CHEMBL235804 | — | — | 1 | 4.04 |
| CHEMBL235372 | — | — | 1 | - |
| CHEMBL392380 | — | — | 1 | - |
| CHEMBL236024 | — | — | 1 | - |
| CHEMBL392379 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235595 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL393606 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL235596 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL235805 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL397791 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL235804 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL235372 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL392380 | — | IC50 | = | 1642000.0 | nM | - |
| CHEMBL236024 | — | IC50 | = | 112400.0 | nM | - |
| CHEMBL392379 | — | IC50 | = | 138000.0 | nM | - |