Assay Detail
Functional
CHEMBL898379
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense after 72 hrs by microplate assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Bicyclo[2.2.2]octyl esters of dialkylamino acids as antiprotozoals.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.00 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.41 |
| CHEMBL235333 | — | — | 1 | 6.68 |
| CHEMBL394001 | — | — | 1 | 6.64 |
| CHEMBL237458 | — | — | 1 | 6.50 |
| CHEMBL237613 | — | — | 1 | 6.43 |
| CHEMBL392520 | — | — | 1 | 6.25 |
| CHEMBL235527 | — | — | 1 | 6.21 |
| CHEMBL235539 | — | — | 1 | 6.21 |
| CHEMBL392519 | — | — | 1 | 6.14 |
| CHEMBL392919 | — | — | 1 | 6.09 |
| CHEMBL235321 | — | — | 1 | 6.08 |
| CHEMBL392729 | — | — | 1 | 6.06 |
| CHEMBL235111 | — | — | 1 | 6.01 |
| CHEMBL443314 | — | — | 1 | 5.98 |
| CHEMBL398994 | — | — | 1 | 5.86 |
| CHEMBL235322 | — | — | 1 | 5.85 |
| CHEMBL237612 | — | — | 1 | 5.70 |
| CHEMBL235112 | — | — | 1 | 5.60 |
| CHEMBL235528 | — | — | 1 | 5.57 |
| CHEMBL374245 | — | — | 1 | 5.53 |
| CHEMBL219419 | — | — | 1 | 5.37 |
| CHEMBL400220 | — | — | 1 | 5.32 |
| CHEMBL400221 | — | — | 1 | 5.31 |
| CHEMBL375980 | — | — | 1 | 5.27 |
| CHEMBL392918 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL235333 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL394001 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL237458 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL237613 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL392520 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL235527 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL235539 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL392519 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL392919 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL235321 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL392729 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL235111 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL443314 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL398994 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL235322 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL237612 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL235112 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL235528 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL374245 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL219419 | — | IC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL400220 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL400221 | — | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL375980 | — | IC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL392918 | — | IC50 | = | 9890.0 | nM | 5.00 |