Assay Detail
Functional
CHEMBL898399
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Antiproliferative activity against human HCT116 cells after 72 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.05 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235934 | CLAUSINE E | — | 1 | 5.72 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.55 |
| CHEMBL236763 | — | — | 1 | 5.15 |
| CHEMBL236764 | — | — | 1 | 5.07 |
| CHEMBL393476 | — | — | 1 | 4.44 |
| CHEMBL236143 | MUKONINE | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235934 | CLAUSINE E | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL236763 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL236764 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL393476 | — | IC50 | = | 36600.0 | nM | 4.44 |
| CHEMBL236143 | MUKONINE | IC50 | = | 43000.0 | nM | 4.37 |