Assay Detail
Functional
CHEMBL898455
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Inhibition of cholesterol synthesis in rat L6 cells after 3 hrs
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.35 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1477 | CERIVASTATIN | 4.0 | 1 | 8.15 |
| CHEMBL237814 | — | — | 1 | 7.58 |
| CHEMBL262322 | — | — | 1 | 7.55 |
| CHEMBL235472 | — | — | 1 | 7.55 |
| CHEMBL427854 | — | — | 1 | 6.99 |
| CHEMBL394937 | — | — | 1 | 6.80 |
| CHEMBL237596 | — | — | 1 | 6.74 |
| CHEMBL1064 | SIMVASTATIN | 4.0 | 1 | 6.64 |
| CHEMBL1496 | ROSUVASTATIN | 4.0 | 1 | 6.14 |
| CHEMBL235712 | — | — | 1 | 5.76 |
| CHEMBL398403 | — | — | 1 | 5.75 |
| CHEMBL392897 | — | — | 1 | 5.28 |
| CHEMBL391241 | — | — | 1 | 4.97 |
| CHEMBL235709 | — | — | 1 | 4.73 |
| CHEMBL237597 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1477 | CERIVASTATIN | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL237814 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL262322 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL235472 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL427854 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL394937 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL237596 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL1064 | SIMVASTATIN | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL1496 | ROSUVASTATIN | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL235712 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL398403 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL392897 | — | IC50 | = | 5225.0 | nM | 5.28 |
| CHEMBL391241 | — | IC50 | = | 10821.0 | nM | 4.97 |
| CHEMBL235709 | — | IC50 | = | 18609.0 | nM | 4.73 |
| CHEMBL237597 | — | IC50 | = | 22701.0 | nM | 4.64 |