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Assay Detail

CHEMBL898609

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity at ERalpha expressed in yeast AH109 assessed as inhibition of 17-beta-estradiol induced alpha-galactosidase activity
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Estrogen receptor (CHEMBL206)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Aza analogues of equol: novel ligands for estrogen receptor beta.
Chen W, Lin Z, Ning M, Yang C, Yan X, Xie Y, Shen X, Wang MW.
Bioorg Med Chem (2007) 15 : 5828 -5836
PubMed 17574424 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.42 5.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL391619 1 5.58
CHEMBL392029 1 5.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL391619 IC50 = 2650.0 nM 5.58
CHEMBL392029 IC50 = 5570.0 nM 5.25