Assay Detail
Binding
CHEMBL898620
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human Dopamine D3 receptor expressed in CHO cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D(4)-selective ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.77 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240996 | — | — | 1 | 7.85 |
| CHEMBL393492 | — | — | 1 | 7.52 |
| CHEMBL240774 | — | — | 1 | 7.45 |
| CHEMBL394110 | — | — | 1 | 7.18 |
| CHEMBL395933 | — | — | 1 | 7.10 |
| CHEMBL398813 | — | — | 1 | 6.99 |
| CHEMBL238916 | — | — | 1 | 6.97 |
| CHEMBL238917 | — | — | 1 | 6.73 |
| CHEMBL394080 | — | — | 1 | 6.71 |
| CHEMBL268371 | — | — | 1 | 6.61 |
| CHEMBL238915 | — | — | 1 | 6.54 |
| CHEMBL239700 | — | — | 1 | 6.51 |
| CHEMBL238717 | — | — | 1 | 6.28 |
| CHEMBL240995 | — | — | 1 | 6.18 |
| CHEMBL239917 | — | — | 1 | 5.92 |
| CHEMBL238718 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240996 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL393492 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL240774 | — | Ki | = | 35.8 | nM | 7.45 |
| CHEMBL394110 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL395933 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL398813 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL238916 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL238917 | — | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL394080 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL268371 | — | Ki | = | 247.0 | nM | 6.61 |
| CHEMBL238915 | — | Ki | = | 287.0 | nM | 6.54 |
| CHEMBL239700 | — | Ki | = | 306.0 | nM | 6.51 |
| CHEMBL238717 | — | Ki | = | 527.0 | nM | 6.28 |
| CHEMBL240995 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL239917 | — | Ki | = | 1204.0 | nM | 5.92 |
| CHEMBL238718 | — | Ki | = | 1780.0 | nM | 5.75 |