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Compound Detail

CHEMBL238718

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O=c1c2ccccc2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1

Basic Information

ChEMBL ID CHEMBL238718
Phase Preclinical
Structure Type MOL
InChI Key RSLKAABRYSOXNC-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

396.9
MW (Da)
3.65
ALogP
5
HBA
0
HBD
41.4
PSA (Ų)
0.60
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H25ClN4O
MW 396.92
Aromatic Rings 3
Heavy Atoms 28
NP-Likeness -1.70

Activity Summary

Ki 4 meas. best 6.85

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(2) dopamine receptor
CHEMBL217
Ki 6.85 6.85 140.0 1
Unchecked
CHEMBL612545
Ki 6.8 6.8 158.0 1
D(1B) dopamine receptor
CHEMBL1850
Ki 6.29 6.29 507.0 1
D(3) dopamine receptor
CHEMBL234
Ki 5.75 5.75 1780.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17576067 10.1016/j.bmc.2007.06.002 D(2) dopamine receptor 4
17576067 10.1016/j.bmc.2007.06.002 D(1B) dopamine receptor 4
17576067 10.1016/j.bmc.2007.06.002 D(3) dopamine receptor 2
17576067 10.1016/j.bmc.2007.06.002 Unchecked 2

Data from ChEMBL 36 via Core Engine