Assay Detail
Functional
CHEMBL898626
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D(4)-selective ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 10 | - | - |
| Ki | 6 | 6.64 | 6.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393492 | — | — | 1 | 6.86 |
| CHEMBL394110 | — | — | 1 | 6.41 |
| CHEMBL240996 | — | — | 1 | - |
| CHEMBL240995 | — | — | 1 | - |
| CHEMBL240774 | — | — | 1 | - |
| CHEMBL394080 | — | — | 1 | - |
| CHEMBL268371 | — | — | 1 | - |
| CHEMBL239917 | — | — | 1 | - |
| CHEMBL395933 | — | — | 1 | - |
| CHEMBL239700 | — | — | 1 | - |
| CHEMBL398813 | — | — | 1 | - |
| CHEMBL238718 | — | — | 1 | - |
| CHEMBL238717 | — | — | 1 | - |
| CHEMBL238917 | — | — | 1 | - |
| CHEMBL238916 | — | — | 1 | - |
| CHEMBL238915 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393492 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL394110 | — | Ki | = | 386.0 | nM | 6.41 |
| CHEMBL240996 | — | Activity | - | — | - | |
| CHEMBL240995 | — | Activity | - | — | - | |
| CHEMBL240774 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL394080 | — | Ki | - | — | - | |
| CHEMBL268371 | — | Activity | - | — | - | |
| CHEMBL239917 | — | Activity | - | — | - | |
| CHEMBL395933 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL239700 | — | Activity | - | — | - | |
| CHEMBL398813 | — | Activity | - | — | - | |
| CHEMBL238718 | — | Ki | - | — | - | |
| CHEMBL238717 | — | Activity | - | — | - | |
| CHEMBL238917 | — | Activity | - | — | - | |
| CHEMBL238916 | — | Activity | - | — | - | |
| CHEMBL238915 | — | Activity | - | — | - |