Assay Detail
Binding
CHEMBL898699
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Inhibition of human recombinant CA 3 assessed as CO2 hydration by stopped flow kinetic assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 4.90 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237251 | PRONTOCIL | — | 1 | 5.64 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | 3.0 | 1 | 5.10 |
| CHEMBL266240 | — | — | 1 | 5.01 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 4.98 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 4.97 |
| CHEMBL306195 | — | — | 1 | 4.97 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 4.95 |
| CHEMBL360356 | — | — | 1 | 4.84 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 4.84 |
| CHEMBL268439 | — | — | 1 | 4.74 |
| CHEMBL69813 | — | — | 1 | 4.72 |
| CHEMBL71611 | — | — | 1 | 4.09 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | - |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | - |
| CHEMBL176495 | — | — | 1 | - |
| CHEMBL6784 | — | — | 1 | - |
| CHEMBL6919 | — | — | 1 | - |
| CHEMBL6633 | — | — | 1 | - |
| CHEMBL7146 | — | — | 1 | - |
| CHEMBL6705 | — | — | 1 | - |
| CHEMBL51668 | — | — | 1 | - |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | - |
| CHEMBL7087 | — | — | 1 | - |
| CHEMBL6853 | — | — | 1 | - |
| CHEMBL7092 | — | — | 1 | - |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | - |
| CHEMBL265674 | — | — | 1 | - |
| CHEMBL6753 | — | — | 1 | - |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | - |
| CHEMBL266026 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237251 | PRONTOCIL | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL266240 | — | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL77517 | INDISULAM | Ki | = | 10400.0 | nM | 4.98 |
| CHEMBL26 | SULPIRIDE | Ki | = | 10600.0 | nM | 4.97 |
| CHEMBL306195 | — | Ki | = | 10700.0 | nM | 4.97 |
| CHEMBL414 | CARZENIDE | Ki | = | 11300.0 | nM | 4.95 |
| CHEMBL360356 | — | Ki | = | 14600.0 | nM | 4.84 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 14300.0 | nM | 4.84 |
| CHEMBL268439 | — | Ki | = | 18100.0 | nM | 4.74 |
| CHEMBL69813 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL71611 | — | Ki | = | 80500.0 | nM | 4.09 |
| CHEMBL6784 | — | Ki | = | 1187000.0 | nM | - |
| CHEMBL176495 | — | Ki | = | 1995000.0 | nM | - |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 236000.0 | nM | - |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 770000.0 | nM | - |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 1113000.0 | nM | - |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 684000.0 | nM | - |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 770000.0 | nM | - |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 110000.0 | nM | - |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 780000.0 | nM | - |
| CHEMBL750 | ZONISAMIDE | Ki | = | 2200000.0 | nM | - |
| CHEMBL310671 | SACCHARIN | Ki | = | 1000000.0 | nM | - |
| CHEMBL118 | CELECOXIB | Ki | = | 154000.0 | nM | - |
| CHEMBL865 | VALDECOXIB | Ki | = | 788000.0 | nM | - |
| CHEMBL6919 | — | Ki | = | 4890000.0 | nM | - |
| CHEMBL6633 | — | Ki | = | 2633000.0 | nM | - |
| CHEMBL7146 | — | Ki | = | 140000.0 | nM | - |
| CHEMBL6705 | — | Ki | = | 887000.0 | nM | - |
| CHEMBL51668 | — | Ki | = | 1060000.0 | nM | - |
| CHEMBL419 | MAFENIDE | Ki | = | 681000.0 | nM | - |
| CHEMBL7087 | — | Ki | = | 1600000.0 | nM | - |
| CHEMBL6853 | — | Ki | = | 2075000.0 | nM | - |
| CHEMBL7092 | — | Ki | = | 710000.0 | nM | - |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 1276000.0 | nM | - |
| CHEMBL265674 | — | Ki | = | 148000.0 | nM | - |
| CHEMBL6753 | — | Ki | = | 198000.0 | nM | - |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 988000.0 | nM | - |
| CHEMBL266026 | — | Ki | = | 114000.0 | nM | - |