Assay Detail
Binding
CHEMBL898810
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Inhibition of human recombinant HDAC4 expressed in 293 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.35 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419758 | — | — | 1 | 7.50 |
| CHEMBL235263 | — | — | 1 | 7.48 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.47 |
| CHEMBL235262 | — | — | 1 | 7.42 |
| CHEMBL236129 | — | — | 1 | 6.89 |
| CHEMBL235918 | — | — | 1 | 6.66 |
| CHEMBL235702 | — | — | 1 | 6.55 |
| CHEMBL391395 | — | — | 1 | 6.51 |
| CHEMBL391396 | — | — | 1 | 6.24 |
| CHEMBL235703 | — | — | 1 | 6.19 |
| CHEMBL235917 | — | — | 1 | 6.14 |
| CHEMBL379049 | — | — | 1 | 6.08 |
| CHEMBL235704 | — | — | 1 | 6.01 |
| CHEMBL213934 | — | — | 1 | 5.99 |
| CHEMBL209551 | — | — | 1 | 5.94 |
| CHEMBL236128 | — | — | 1 | 5.94 |
| CHEMBL235909 | — | — | 1 | 5.72 |
| CHEMBL393827 | — | — | 1 | 5.38 |
| CHEMBL235911 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419758 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL235263 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL235262 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL236129 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL235918 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL235702 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL391395 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL391396 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL235703 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL235917 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL379049 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL235704 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL213934 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL209551 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL236128 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL235909 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL393827 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL235911 | — | IC50 | = | 31200.0 | nM | 4.51 |