Assay Detail
Binding
CHEMBL898811
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Inhibition of mouse recombinant HDAC6 expressed in 293 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.97 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379049 | — | — | 1 | 7.64 |
| CHEMBL213934 | — | — | 1 | 7.54 |
| CHEMBL235263 | — | — | 1 | 7.50 |
| CHEMBL209551 | — | — | 1 | 7.44 |
| CHEMBL419758 | — | — | 1 | 7.39 |
| CHEMBL235262 | — | — | 1 | 7.27 |
| CHEMBL235909 | — | — | 1 | 7.15 |
| CHEMBL236129 | — | — | 1 | 7.11 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.09 |
| CHEMBL393827 | — | — | 1 | 7.09 |
| CHEMBL391395 | — | — | 1 | 7.00 |
| CHEMBL236128 | — | — | 1 | 6.92 |
| CHEMBL391396 | — | — | 1 | 6.92 |
| CHEMBL235704 | — | — | 1 | 6.82 |
| CHEMBL235918 | — | — | 1 | 6.77 |
| CHEMBL235702 | — | — | 1 | 6.72 |
| CHEMBL235917 | — | — | 1 | 6.37 |
| CHEMBL235703 | — | — | 1 | 6.29 |
| CHEMBL235911 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379049 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL213934 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL235263 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL209551 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL419758 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL235262 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL235909 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL236129 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL393827 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL391395 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL236128 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL391396 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL235704 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL235918 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL235702 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL235917 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL235703 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL235911 | — | IC50 | = | 3860.0 | nM | 5.41 |