Assay Detail
Binding
CHEMBL898849
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Inhibition of human DPP8
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.64 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392524 | — | — | 1 | 5.44 |
| CHEMBL237152 | — | — | 1 | 5.37 |
| CHEMBL237151 | — | — | 1 | 5.19 |
| CHEMBL235199 | — | — | 1 | 4.66 |
| CHEMBL237547 | — | — | 1 | 4.60 |
| CHEMBL437557 | — | — | 1 | 4.52 |
| CHEMBL237997 | — | — | 1 | 4.48 |
| CHEMBL238190 | — | — | 1 | 4.39 |
| CHEMBL400841 | — | — | 1 | 4.28 |
| CHEMBL237336 | — | — | 1 | 4.06 |
| CHEMBL237783 | — | — | 1 | 4.02 |
| CHEMBL235004 | — | — | 1 | - |
| CHEMBL235223 | — | — | 1 | - |
| CHEMBL237972 | — | — | 1 | - |
| CHEMBL238191 | — | — | 1 | - |
| CHEMBL235198 | — | — | 1 | - |
| CHEMBL237566 | — | — | 1 | - |
| CHEMBL237119 | — | — | 1 | - |
| CHEMBL237337 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392524 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL237152 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL237151 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL235199 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL237547 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL437557 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL237997 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL238190 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL400841 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL237336 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL237783 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL235004 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL235223 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL237972 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL238191 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL235198 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL237566 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL237119 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL237337 | — | IC50 | > | 100000.0 | nM | - |